According to research published in EBioMedicine.
We wished to develop a mouse model researchers could use to study ways of preventing breasts and ovarian cancer in women with BRCA1 and BRCA2 mutations. We wish this can lead to new approaches which will eliminate the dependence on surgery in the future. More research is needed into the new avoidance strategies. Prof. Widschwendter and the united group want to test the effectiveness of OPG in preventing breast cancer, but until they are totally sure it works they can not conduct a clinical trial to see if OPG prevents tumor development. Instead, in addition to taking advantage of the brand new mouse model developed in Prof. Dubeau's laboratory, they plan to trial treatment on females at high risk of breast cancer who have are waiting for preventative surgery. Instead of waiting for cancer to build up, the trial will monitor biological changes in the tissues vulnerable to tumor to evaluate the result of treatment on cancer prevention.A limitation of the study is the relatively large numbers of patients who switched from correct ventricular pacing to biventricular pacing. However, a considerable proportion of these crossovers happened after a primary outcome event had occurred in the patient. Furthermore, given the intention-to-treat design, this phenomenon would probably have skewed the info in favor of correct ventricular pacing and weakened the overall findings of the study.