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Cristina Quarta.

C levitra reviews . Cristina Quarta, M.D., Joel N. Buxbaum, M.D., Amil M. Shah, M.D., M.P.H., Rodney H. Falk, M.D., Brian Claggett, Ph.D., Dalane W. Kitzman, M.D., Thomas H. Mosley, Ph.D., Kenneth R. Butler, Ph.D., Eric Boerwinkle, Ph.D., and Scott D. Solomon, M.D.: The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans Amyloid heart disease leads to a rise in ventricular wall thickness and stiffness of the heart.1 Abnormalities of transthyretin, a transport protein synthesized mainly by the liver, may lead to hereditary transthyretin-related amyloidosis.2 This disorder could be caused by anybody of more than 100 stage mutations in the transthyretin gene ; the V122I variant, where isoleucine is normally substituted for valine at position 122, is the most typical mutation and takes place in 3 to 4 percent of black Americans.3-5 V122I reduces the stability of transthyretin tetramers, causing cardiac deposition of misfolded transthyretin monomers and resulting in an autosomal dominant cardiomyopathy that typically occurs during or after the sixth decade of lifestyle, with a penetrance believed to be as high as 80 percent among men.6-9 The variant has been connected with increased risks of heart failure and death.