Including internal calcium transients in the current presence of ATP.
75 percent of cell plasma membrane reversibly endocytosed In three papers in the January and February issues of the Journal of General Physiology , Don Hilgemann and colleagues have extensively characterized a previously unidentified process by which up to 75 percent of the cell plasma membrane can be reversibly endocytosed. This massive endocytosis could be elicited in a variety of cell types with a range of different experimental manipulations, including internal calcium transients in the current presence of ATP, membrane treatment with sphingomyelinase, and introduction of various amphiphiles in to the membrane bilayer. MEND will not employ the canonical endocytic mechanisms involving clathrin, the actin dynamins or cytoskeleton ed help .
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