Timothy A her . Brighton, M.B., B.S., John W. Eikelboom, M.B., B.S., Kristy Mann, M.Biostat., Rebecca Mister, M.Sc., Alexander Gallus, M.B., B.S., Paul Ockelford, M.B., Harry Gibbs, M.B., Wendy Hague, Ph.D., Denis Xavier, M.Sc., Rafael Diaz, M.D., Adrienne Kirby, M.Sc., and John Simes, M.D. For the ASPIRE Investigators: Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism Patients who have had a first bout of unprovoked venous thromboembolism are in risky for recurrence after anticoagulant therapy is discontinued.1-4 Long-term treatment with a vitamin K antagonist is very effective in preventing a recurrence of venous thromboembolism even though treatment continues5 but has not been shown to improve survival, is associated with a substantially increased threat of bleeding, and is inconvenient for individuals.6-10 Consequently, many patients who’ve had a first episode of unprovoked venous thromboembolism discontinue anticoagulant therapy after 3 to 6 months despite recommendations to prolong therapy.5 Low-dose aspirin is normally a straightforward, inexpensive, and widely available treatment that’s effective for preventing arterial vascular events and for the principal prevention of venous thromboembolism in high-risk surgical sufferers.11-13 Aspirin may also be effective in preventing a recurrence of venous thromboembolism following a first event.14 The objective of our study was to judge the efficacy of low-dose aspirin, as compared with placebo, in stopping a recurrence of venous thromboembolism in patients who had completed initial anticoagulation with warfarin after an initial unprovoked bout of venous thromboembolism.
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