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This work is of great interest because it could herald a new approach in the treatment of type 2 diabetes and obesity. ‘Recently, two classes of drugs using the properties of the hormone GLP – 1 for the treatment of type 2 diabetes. The first strategy blood levels blood levels of GLP-1 by limiting to its degradation in the body. The second is that the effects mimic GLP-1 drug drug activation of the GLP – 1 receptor , ‘says Charles Thomas, the author of the study. In this study, the one third third therapeutic option to increase GLP – 1 secretion by the administration of TGR5 agonist therapy is based. The results obtained by the authors even more spectacular since in addition to stimulating the secretion of GLP-1, RC-777 activation of TGR5 in other tissues leads to an increase in energy consumption for a reduction in fat mass and obesity.
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